Comparison of Mucosal, Subcutaneous and Intraperitoneal Routes of Rat Leptospira Infection.

ABSTRACT: Leptospirosis is a zoonosis found worldwide that is caused by a spirochete. The main reservoirs of Leptospira, which presents an asymptomatic infection, are wild rodents, including the brown rat (Rattus norvegicus). Experimental studies of the mechanisms of its renal colonization in rats have previously used an intraperitoneal inoculation route. However, knowledge of rat-rat transmission requires the use of a natural route of inoculation, such as a mucosal or subcutaneous route. We investigated for the first time the effects of subcutaneous and mucosal inoculation routes compared to the reference intraperitoneal route during Leptospira infection in adult rats. Infection characteristics were studied using Leptospira renal isolation, serology, and molecular and histological analyses. Leptosp

SUBMITTER: Zilber AL 

PROVIDER: S-EPMC4816568 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature