Pioglitazone use and risk of bladder cancer: population based cohort study.

ABSTRACT:

Objective

To determine whether pioglitazone compared with other antidiabetic drugs is associated with an increased risk of bladder cancer in people with type 2 diabetes.

Design

Population based cohort study.

Setting

General practices contributing data to the United Kingdom Clinical Practice Research Datalink.

Participants

A cohort of 145,806 patients newly treated with antidiabetic drugs between 1 January 2000 and 31 July 2013, with follow-up until 31 July 2014.

Main outcome measures

The use of pioglitazone was treated as a time varying variable, with use lagged by one year for latency purposes. Cox proportional hazards models were used to estimate adjusted hazard ratios with 95% confidence intervals of incident bladder cancer associated with pioglitazon

SUBMITTER: Tuccori M 

PROVIDER: S-EPMC4816602 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature