Diabetes treatments and risk of amputation, blindness, severe kidney failure, hyperglycaemia, and hypoglycaemia: open cohort study in primary care.

ABSTRACT:

Objective

To assess the risks of amputation, blindness, severe kidney failure, hyperglycaemia, and hypoglycaemia in patients with type 2 diabetes associated with prescribed diabetes drugs, particularly newer agents including gliptins or glitazones (thiazolidinediones).

Design

Open cohort study in primary care.

Setting

1243 practices contributing data to the QResearch database in England.

Participants

469,688 patients with type 2 diabetes aged 25-84 years between 1 April 2007 and 31 January 2015.

Exposures

Hypoglycaemic agents (glitazones, gliptins, metformin, sulphonylureas, insulin, and other) alone and in combination.

Main outcome measures

First recorded diagnoses of amputation, blindness, severe kidney failure, hyperglycaemia, and hypoglycaemia

SUBMITTER: Hippisley-Cox J 

PROVIDER: S-EPMC4816603 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature