Structural Fluctuations of the Chromatin Fiber within Topologically Associating Domains.

ABSTRACT: Experiments based on chromosome conformation capture have shown that mammalian genomes are partitioned into topologically associating domains (TADs), within which the chromatin fiber preferentially interacts. TADs may provide three-dimensional scaffolds allowing genes to contact their appropriate distal regulatory DNA sequences (e.g., enhancers) and thus to be properly regulated. Understanding the cell-to-cell and temporal variability of the chromatin fiber within TADs, and what determines them, is thus of great importance to better understand transcriptional regulation. We recently described an equilibrium polymer model that can accurately predict cell-to-cell variation of chromosome conformation within single TADs, from chromosome conformation capture-based data. Here we further analyze

SUBMITTER: Tiana G 

PROVIDER: S-EPMC4816701 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature