Postponing the Hypoglycemic Response to Partial Hepatectomy Delays Mouse Liver Regeneration.

ABSTRACT: All serious liver injuries alter metabolism and initiate hepatic regeneration. Recent studies using partial hepatectomy (PH) and other experimental models of liver regeneration implicate the metabolic response to hepatic insufficiency as an important source of signals that promote regeneration. Based on these considerations, the analyses reported here were undertaken to assess the impact of interrupting the hypoglycemic response to PH on liver regeneration in mice. A regimen of parenteral dextrose infusion that delays PH-induced hypoglycemia for 14 hours after surgery was identified, and the hepatic regenerative response to PH was compared between dextrose-treated and control mice. The results showed that regenerative recovery of the liver was postponed in dextrose-infused mice (versus veh

SUBMITTER: Huang J 

PROVIDER: S-EPMC4816713 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature