White Matter Connectivity of the Thalamus Delineates the Functional Architecture of Competing Thalamocortical Systems.

ABSTRACT: There is an increasing awareness of the involvement of thalamic connectivity on higher level cortical functioning in the human brain. This is reflected by the influence of thalamic stimulation on cortical activity and behavior as well as apparently cortical lesion syndromes occurring as a function of small thalamic insults. Here, we attempt to noninvasively test the correspondence of structural and functional connectivity of the human thalamus using diffusion-weighted and resting-state functional MRI. Using a large sample of 102 adults, we apply tensor independent component analysis to diffusion MRI tractography data to blindly parcellate bilateral thalamus according to diffusion tractography-defined structural connectivity. Using resting-state functional MRI collected in the same subjects

SUBMITTER: O'Muircheartaigh J 

PROVIDER: S-EPMC4816794 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature