The effects of soy supplementation on gene expression in breast cancer: a randomized placebo-controlled study.

ABSTRACT:

Background

There are conflicting reports on the impact of soy on breast carcinogenesis. This study examines the effects of soy supplementation on breast cancer-related genes and pathways.

Methods

Women (n = 140) with early-stage breast cancer were randomly assigned to soy protein supplementation (n = 70) or placebo (n = 70) for 7 to 30 days, from diagnosis until surgery. Adherence was determined by plasma isoflavones: genistein and daidzein. Gene expression changes were evaluated by NanoString in pre- and posttreatment tumor tissue. Genome-wide expression analysis was performed on posttreatment tissue. Proliferation (Ki67) and apoptosis (Cas3) were assessed by immunohistochemistry.

Results

Plasma isoflavones rose in the soy group (two-sided Wilcoxon rank-sum test, P <

SUBMITTER: Shike M 

PROVIDER: S-EPMC4817128 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature