BDNF Val66Met Polymorphism Is Related to Motor System Function After Stroke.

ABSTRACT:

Background

The val(66)met polymorphism in brain-derived neurotrophic factor (BDNF) has been associated with poorer outcomes after stroke. The mechanism for this finding remains uncertain but might be related to the reduced motor system activation associated with this polymorphism in healthy people.

Objective

The current study examined whether the presence of the BDNF val(66)met polymorphism is associated with reduced motor system activation after stroke.

Design and methods

Forty-two patients with stroke who were enrolled in 1 of 2 studies of robot-assisted arm motor therapy participated in the study. All participants were tested for the BDNF val(66)met polymorphism followed by functional magnetic resonance imaging during affected hand movement.

Results

Particip

SUBMITTER: Kim DY 

PROVIDER: S-EPMC4817211 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature