Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation.

ABSTRACT:

Unlabelled

Middle East respiratory syndrome coronavirus (MERS-CoV) is the first highly pathogenic human coronavirus to emerge since severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002. Like many coronaviruses, MERS-CoV carries genes that encode multiple accessory proteins that are not required for replication of the genome but are likely involved in pathogenesis. Evasion of host innate immunity through interferon (IFN) antagonism is a critical component of viral pathogenesis. The IFN-inducible oligoadenylate synthetase (OAS)-RNase L pathway activates upon sensing of viral double-stranded RNA (dsRNA). Activated RNase L cleaves viral and host single-stranded RNA (ssRNA), which leads to translational arrest and subsequent cell death, preventing viral replication and sprea

SUBMITTER: Thornbrough JM 

PROVIDER: S-EPMC4817253 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature