Serological response to Helicobacter pylori infection among Latin American populations with contrasting risks of gastric cancer.

ABSTRACT: Gastric cancer is a rare outcome of chronic Helicobacter pylori infection. Serologic profiles may reveal bacterial, environmental and/or host factors associated with cancer risk. We therefore compared specific anti-H. pylori antibodies among populations with at least twofold differences in gastric cancer mortality from Mexico, Colombia and Chile. Our study included 1,776 adults (mean age 42 years) from three nationally representative surveys, equally divided between residents of high- and low-risk areas. Antibodies to 15 immunogenic H. pylori antigens were measured by fluorescent bead-based multiplex assays; results were summarized to identify overall H. pylori seropositivity. We used logistic regression to model associations between antibody seroreactivity and regional cancer risk (high v

SUBMITTER: Camargo MC 

PROVIDER: S-EPMC4817269 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature