Genetic analysis of Iranian family with hereditary cardiac arrhythmias by next generation sequencing.

ABSTRACT:

Background

Cardiac arrhythmias are responsible for several cases of syncope and sudden cardiac death annually worldwide. Due to overlapping clinical symptoms in some cardiac arrhythmias genetic studies would help to confirm the primary clinical diagnosis made on the basis of solely clinical findings. In addition clinical management of the patient, family screening and provide appropriate counseling and risk assessment for the family members are other advantages of genetic study.

Materials and methods

Totally nine patients from a family included in this study. The primary diagnosis on the basis of clinical findings was second-degree atrioventricular (AV) block for this family. Mutation in SCN5A gene is frequently reported for second-degree AV block and hence the gene was anal

SUBMITTER: Asadi M 

PROVIDER: S-EPMC4817390 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature