β-C(sp(3))-H Arylation of α-Hydroxy Acid Derivatives Utilizing Amino Acid as a Directing Group.

ABSTRACT: The Pd(II)-catalyzed arylation of unactivated β-C(sp(3))-H bonds in α-hydroxy aliphatic acid with a variety of aryl iodides was developed utilizing an amino acid auxiliary as a directing group. This protocol provides access to biologically active β-arylated-α-hydroxy acid derivatives.

SUBMITTER: Toba T 

PROVIDER: S-EPMC4817547 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature