An Insight Into the Immunologic Events and Risk Assessment in Renal Transplantation.

ABSTRACT: Organ transplantation has always been considered to be the optimal therapeutic intervention in patients with end-stage organ failure. In the US, approximately 615,000 patients are diagnosed with end-stage renal disease and less than 30% have received a kidney transplant. One of the crucial drawbacks in successful renal transplantation is allograft rejection. Survival rates among transplant recipients have greatly improved due to better understanding of transplant biology and more effective immunosuppressive agents. Post-transplant immune monitoring and optimization of the immunosuppressive therapy using non-invasive biomarkers can effectively predict impending graft rejection and may spare the need for renal biopsy. This article provides an insight into the immunomodulations of renal trans

SUBMITTER: Khan A 

PROVIDER: S-EPMC4817575 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature