Action of obestatin in skeletal muscle repair: stem cell expansion, muscle growth, and microenvironment remodeling.

ABSTRACT: The development of therapeutic strategies for skeletal muscle diseases, such as physical injuries and myopathies, depends on the knowledge of regulatory signals that control the myogenic process. The obestatin/GPR39 system operates as an autocrine signal in the regulation of skeletal myogenesis. Using a mouse model of skeletal muscle regeneration after injury and several cellular strategies, we explored the potential use of obestatin as a therapeutic agent for the treatment of trauma-induced muscle injuries. Our results evidenced that the overexpression of the preproghrelin, and thus obestatin, and GPR39 in skeletal muscle increased regeneration after muscle injury. More importantly, the intramuscular injection of obestatin significantly enhanced muscle regeneration by simulating satellite

SUBMITTER: Gurriaran-Rodriguez U 

PROVIDER: S-EPMC4817756 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature