Morphogenesis of the C. elegans Intestine Involves Axon Guidance Genes.

ABSTRACT: Genetic and molecular studies have provided considerable insight into how various tissue progenitors are specified in early embryogenesis, but much less is known about how those progenitors create three-dimensional tissues and organs. The C. elegans intestine provides a simple system for studying how a single progenitor, the E blastomere, builds an epithelial tube of 20 cells. As the E descendants divide, they form a primordium that transitions between different shapes over time. We used cell contours, traced from confocal optical z-stacks, to build a 3D graphic reconstruction of intestine development. The reconstruction revealed several new aspects of morphogenesis that extend and clarify previous observations. The first 8 E descendants form a plane of four right cells and four left cells

SUBMITTER: Asan A 

PROVIDER: S-EPMC4817974 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature