Secondary Solid Organ Neoplasm in Patients with Acute Lymphoblastic Leukemia: A Nationwide Population-Based Study in Taiwan.

ABSTRACT:

Background

Acute lymphoblastic leukemia (ALL) is more common in children than in adults. Secondary neoplasms (SNs) in childhood ALL have been widely reported. However, only one study has demonstrated SNs in adult ALL. Because of the poorer survival of adult ALL, the incidence might be underestimated.

Objective

To evaluate the incidence and risk factors of secondary solid organ neoplasms among adult and child ALL patients.

Methods

Newly diagnosed ALL patients between 1997 and 2011 were recruited from the Taiwan National Health Insurance database. Those who had antecedent or combined malignancies were excluded. Standardized incidence ratios (SIRs) were analyzed to compare the risk of our cohort to general population in the same age, sex and calendar year. Risk factors f

SUBMITTER: Teng CJ 

PROVIDER: S-EPMC4817987 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature