Staphylococcus aureus Transcriptome Architecture: From Laboratory to Infection-Mimicking Conditions.

ABSTRACT: Staphylococcus aureus is a major pathogen that colonizes about 20% of the human population. Intriguingly, this Gram-positive bacterium can survive and thrive under a wide range of different conditions, both inside and outside the human body. Here, we investigated the transcriptional adaptation of S. aureus HG001, a derivative of strain NCTC 8325, across experimental conditions ranging from optimal growth in vitro to intracellular growth in host cells. These data establish an extensive repertoire of transcription units and non-coding RNAs, a classification of 1412 promoters according to their dependence on the RNA polymerase sigma factors SigA or SigB, and allow identification of new potential targets for several known transcription factors. In particular, this study revealed a relatively l

SUBMITTER: Mader U 

PROVIDER: S-EPMC4818034 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature