Prognostic Value of Galectin-3 for Adverse Outcomes in Chronic Heart Failure.

ABSTRACT:

Background

Clinical studies have suggested the prognostic value of galectin-3, a marker of fibrosis, in chronic heart failure. However, the specific role of galectin-3, compared with established biomarkers, remains uncertain.

Methods and results

The Penn Heart Failure Study was an ambulatory heart failure cohort that included 1385 participants with reduced (1141), preserved (106), and recovered (138) left ventricular ejection fraction (LVEF). Cox regression models determined the association between galectin-3 and risk of all-cause mortality, cardiac transplantation, or placement of a ventricular assist device. Receiver operating characteristic curves compared the prognostic accuracy of galectin-3, high-sensitivity soluble Toll-like receptor 2 (ST2), troponin I, and B-type na

SUBMITTER: French B 

PROVIDER: S-EPMC4818189 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature