Functional Tuning of Intrinsic Endothelial Ca2+ Dynamics in Swine Coronary Arteries.

ABSTRACT:

Rationale

Recent data from mesenteric and cerebral beds have revealed spatially restricted Ca(2+) transients occurring along the vascular intima that control effector recruitment and vasodilation. Although Ca(2+) is pivotal for coronary artery endothelial function, spatial and temporal regulation of functional Ca(2+) signals in the coronary endothelium is poorly understood.

Objective

We aimed to determine whether a discrete spatial and temporal profile of Ca(2+) dynamics underlies endothelium-dependent relaxation of swine coronary arteries.

Methods and results

Using confocal imaging, custom automated image analysis, and myography, we show that the swine coronary artery endothelium generates discrete basal Ca(2+) dynamics, including isolated transients and whole-cell p

SUBMITTER: Francis M 

PROVIDER: S-EPMC4818197 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature