Expression profile of androgen-modulated microRNAs in the fetal murine lung.

ABSTRACT:

Background

Androgens are known to delay lung development. As a consequence, the incidence and morbidity of respiratory distress syndrome of the neonate are higher for male than for female premature infants. We previously reported that many genes were expressed with a sex difference in the mouse developing lung and that several genes were under the control of androgens in the male fetal lung. microRNAs are small non-coding RNAs known to negatively regulate the expression of specific genes. In this study, we examined whether murine miRNAs are under the control of androgens in the male developing lung.

Methods

Expression profiling of microRNAs was performed by microarrays using RNA extracted from male fetal lungs isolated on gestational day (GD) 17.0 and GD 18.0 after daily inj

SUBMITTER: Bouhaddioui W 

PROVIDER: S-EPMC4818395 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature