A frameshift mutation in GON4L is associated with proportionate dwarfism in Fleckvieh cattle.

ABSTRACT:

Background

Low birth weight and postnatal growth restriction are the most evident symptoms of dwarfism. Accompanying skeletal aberrations may compromise the general condition and locomotion of affected individuals. Several paternal half-sibs with a low birth weight and a small size were born in 2013 in the Fleckvieh cattle population.

Results

Affected calves were strikingly underweight at birth in spite of a normal gestation length and had craniofacial abnormalities such as elongated narrow heads and brachygnathia inferior. In spite of a normal general condition, their growth remained restricted during rearing. We genotyped 27 affected and 10,454 unaffected animals at 44,672 single nucleotide polymorphisms and performed association tests followed by homozygosity mapping, whi

SUBMITTER: Schwarzenbacher H 

PROVIDER: S-EPMC4818447 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature