Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration.

ABSTRACT:

Objective

To investigate the influence of common and low-frequency genetic variants on the risk of ischemic stroke (all IS) and etiologic stroke subtypes.

Methods

We meta-analyzed 12 individual genome-wide association studies comprising 10,307 cases and 19,326 controls imputed to the 1000 Genomes (1 KG) phase I reference panel. We selected variants showing the highest degree of association (p < 1E-5) in the discovery phase for replication in Caucasian (13,435 cases and 29,269 controls) and South Asian (2,385 cases and 5,193 controls) samples followed by a transethnic meta-analysis. We further investigated the p value distribution for different bins of allele frequencies for all IS and stroke subtypes.

Results

We showed genome-wide significance for 4 loci: ABO for all

SUBMITTER: Malik R 

PROVIDER: S-EPMC4818561 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature