Chronic kidney disease, cerebral blood flow, and white matter volume in hypertensive adults.

ABSTRACT:

Objective

To determine the relation between markers of kidney disease-estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (UACR)-with cerebral blood flow (CBF) and white matter volume (WMV) in hypertensive adults.

Methods

We used baseline data collected from 665 nondiabetic hypertensive adults aged ≥50 years participating in the Systolic Blood Pressure Intervention Trial (SPRINT). We used arterial spin labeling to measure CBF and structural 3T images to segment tissue into normal and abnormal WMV. We used quantile regression to estimate the association between eGFR and UACR with CBF and abnormal WMV, adjusting for sociodemographic and clinical characteristics.

Results

There were 218 participants (33%) with eGFR <60 mL/min/1.73 m(2) and 14

SUBMITTER: Tamura MK 

PROVIDER: S-EPMC4818564 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature