Endoscopic and Pathologic Characterization of Papillary Architecture in Struvite Stone Formers.

ABSTRACT:

Objective

To describe the endoscopic characteristics of renal papillae in struvite stone formers (SFs).

Materials and methods

From 2009 to 2014, patients undergoing percutaneous nephrolithotomy were prospectively enrolled in our study. Endoscopic analysis and biopsy of papillae were performed to demonstrate the presence and percentage surface area (SA) of Randall's plaque or ductal plug. Comparison with idiopathic calcium oxalate (CaOx) SF and non-SF controls was performed.

Results

We identified 29 struvite SFs to compare with 90 idiopathic CaOx SFs and 17 controls. On endoscopic mapping, 28 struvite SFs (97%) demonstrated Randall's plaque and 9 (31%) had plugging. The average mean SA of Randall's plaque in struvite SF (1.5 ± 1.4%) was less than CaOx SFs (3.7 ± 4.3%,

SUBMITTER: Jaeger CD 

PROVIDER: S-EPMC4818656 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature