Exposure to multiple sources of polycyclic aromatic hydrocarbons and breast cancer incidence.

ABSTRACT:

Background

Despite studies having consistently linked exposure to single-source polycyclic aromatic hydrocarbons (PAHs) to breast cancer, it is unclear whether single sources or specific groups of PAH sources should be targeted for breast cancer risk reduction.

Objectives

This study considers the impact on breast cancer incidence from multiple PAH exposure sources in a single model, which better reflects exposure to these complex mixtures.

Methods

In a population-based case-control study conducted on Long Island, New York (N=1508 breast cancer cases/1556 controls), a Bayesian hierarchical regression approach was used to estimate adjusted posterior means and credible intervals (CrI) for the adjusted odds ratios (ORs) for PAH exposure sources, considered singly and as g

SUBMITTER: White AJ 

PROVIDER: S-EPMC4818720 | biostudies-literature | 2016 Apr-May

REPOSITORIES: biostudies-literature