A randomized placebo-controlled lovastatin trial for neurobehavioral function in neurofibromatosis I.

ABSTRACT:

Objective

Lovastatin has been shown to reverse learning deficits in a mouse model of Neurofibromatosis Type 1 (NF1), a common monogenic disorder caused by a mutation in the Ras-MAPK pathway and associated with learning disabilities. We conducted a randomized double-blind placebo-controlled trial to assess lovastatin's effects on cognition and behavior in patients with NF1.

Method

Forty-four NF1 patients (mean age 25.7+/-11.6 years; 64% female) were randomly assigned to 14 weeks of lovastatin (N = 23; maximum dose of 80 mg/day for adult participants and 40 mg/day for children) or placebo (N = 21). Based on findings in the mouse model, primary outcome measures were nonverbal learning and working memory. Secondary outcome measures included verbal memory, attention, and self/par

SUBMITTER: Bearden CE 

PROVIDER: S-EPMC4818747 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature