Preoperative statin administration does not protect against early postoperative acute respiratory distress syndrome: a retrospective cohort study.

ABSTRACT:

Background

Statins have been shown to possess antiinflammatory and immunomodulatory effects. In this study, we sought to determine if preoperative statin therapy is associated with a reduced frequency of postoperative acute respiratory distress syndrome (ARDS) in surgical populations at increased risk of developing ARDS.

Methods

We performed a retrospective cohort evaluation of the association between preoperative statin therapy and early postoperative ARDS in patients undergoing elective high-risk thoracic and aortic vascular surgery. The association between preoperative statin therapy and postoperative ARDS was assessed using propensity-adjusted analyses to control for indication bias and confounding factors.

Results

Of 1845 patients, 722 were receiving preoperative

SUBMITTER: Yadav H 

PROVIDER: S-EPMC4819006 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature