Identification and Evolutionary Analysis of Potential Candidate Genes in a Human Eating Disorder.

ABSTRACT: The purpose of this study was to find genes linked with eating disorders and associated with both metabolic and neural systems. Our operating hypothesis was that there are genetic factors underlying some eating disorders resting in both those pathways. Specifically, we are interested in disorders that may rest in both sleep and metabolic function, generally called Night Eating Syndrome (NES). A meta-analysis of the Gene Expression Omnibus targeting the mammalian nervous system, sleep, and obesity studies was performed, yielding numerous genes of interest. Through a text-based analysis of the results, a number of potential candidate genes were identified. VGF, in particular, appeared to be relevant both to obesity and, broadly, to brain or neural development. VGF is a highly connected prote

SUBMITTER: Sabbagh U 

PROVIDER: S-EPMC4819096 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature