Controlled Multi-functionalization Facilitates Targeted Delivery of Nanoparticles to Cancer Cells.

ABSTRACT: A major objective of nanomedicine is to combine in a controlled manner multiple functional entities into a single nanoscale device to target particles with great spatial precision, thereby increasing the selectivity and potency of therapeutic drugs. A multifunctional nanoparticle is described for controlled conjugation of a cytotoxic drug, a cancer cell targeting ligand, and an imaging moiety. The approach is based on the chemical synthesis of polyethylene glycol that at one end is modified by a thioctic acid for controlled attachment to a gold core. The other end of the PEG polymers is modified by a hydrazine, amine, or dibenzocyclooctynol moiety for conjugation with functional entities having a ketone, activated ester, or azide moiety, respectively. The conjugation approach allowed the c

SUBMITTER: Hudlikar MS 

PROVIDER: S-EPMC4819120 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature