Lower Levels of Urinary Nerve Growth Factor Might Predict Recurrent Urinary Tract Infections in Women.

ABSTRACT:

Purpose

To investigate the changes in urinary nerve growth factor (uNGF) levels after acute urinary tract infection (UTI) and to assess the role of uNGF in predicting UTI recurrence in women.

Methods

Women with uncomplicated, symptomatic UTIs were enrolled. Cephalexin 500 mg (every 6 hours) was administered for 7-14 days to treat acute UTIs. Subsequently, the patients were randomized to receive either sulfamethoxazole/trimethoprim 800 mg/160 mg daily at bedtime, or celecoxib 200 mg daily for 3 months and were monitored for up to 12 months. NGF levels in the urine were determined at baseline, 1, 4, and 12 weeks after the initiation of prophylactic therapy, and were compared between women with first-time UTIs and recurrent UTIs, sulfamethoxazole/trimethoprim and celecoxib-trea

SUBMITTER: Chuang FC 

PROVIDER: S-EPMC4819159 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature