Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth.

ABSTRACT: The development of life-threatening cancer metastases at distant organs requires disseminated tumour cells' adaptation to, and co-evolution with, the drastically different microenvironments of metastatic sites. Cancer cells of common origin manifest distinct gene expression patterns after metastasizing to different organs. Clearly, the dynamic interaction between metastatic tumour cells and extrinsic signals at individual metastatic organ sites critically effects the subsequent metastatic outgrowth. Yet, it is unclear when and how disseminated tumour cells acquire the essential traits from the microenvironment of metastatic organs that prime their subsequent outgrowth. Here we show that both human and mouse tumour cells with normal expression of PTEN, an important tumour suppressor, lose P

SUBMITTER: Zhang L 

PROVIDER: S-EPMC4819404 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature