Assessing incremental value of biomarkers with multi-phase nested case-control studies.

ABSTRACT: Accurate risk prediction models are needed to identify different risk groups for individualized prevention and treatment strategies. In the Nurses' Health Study, to examine the effects of several biomarkers and genetic markers on the risk of rheumatoid arthritis (RA), a three-phase nested case-control (NCC) design was conducted, in which two sequential NCC subcohorts were formed with one nested within the other, and one set of new markers measured on each of the subcohorts. One objective of the study is to evaluate clinical values of novel biomarkers in improving upon existing risk models because of potential cost associated with assaying biomarkers. In this paper, we develop robust statistical procedures for constructing risk prediction models for RA and estimating the incremental value (

SUBMITTER: Zhou QM 

PROVIDER: S-EPMC4819437 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature