Intranasal Fluticasone Propionate Observational Cohort Safety Studies: Reviewing Evidence from Databases on Two Continents.

ABSTRACT:

Purpose

Our objective was to highlight the importance of database selection in observational research and to determine the incidence of corticosteroid-related events in patients exposed to fluticasone propionate intranasal spray (FPNS) compared with other intranasal steroids (INS).

Methods

After a feasibility study using an electronic medical record database in the UK (1990-2002), a retrospective cohort study was conducted using a large administrative claims database in the USA from 1994 to 2002 comparing the incidence and rate ratios of steroid-related events among intermittent, sub-chronic, and chronic FPNS use and other INS use episodes.

Results

Most patients used INS intermittently; power was low to evaluate risk associated with chronic use. Significantly elevated

SUBMITTER: Davis KJ 

PROVIDER: S-EPMC4819470 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature