A novel gene expression signature for bone metastasis in breast carcinomas.

ABSTRACT: Metastatic cancer remains the leading cause of death for patients with breast cancer. To understand the mechanisms underlying the development of distant metastases to specific sites is therefore important and of potential clinical value. From 157 primary breast tumours of the patients with known metastatic disease, gene expression profiling data were generated and correlated to metastatic behaviour including site-specific metastasis, metastasis pattern and survival outcomes. We analysed gene expression signatures specifically associated with the development of bone metastases. As a validation cohort, we used a published dataset of 376 breast carcinomas for which gene expression data and site-specific metastasis information were available. 80.5 % of luminal-type tumours developed bone metas

SUBMITTER: Savci-Heijink CD 

PROVIDER: S-EPMC4819548 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature