Gene expression analysis reveals that Delta/Notch signalling is not involved in onychophoran segmentation.

ABSTRACT: Delta/Notch (Dl/N) signalling is involved in the gene regulatory network underlying the segmentation process in vertebrates and possibly also in annelids and arthropods, leading to the hypothesis that segmentation may have evolved in the last common ancestor of bilaterian animals. Because of seemingly contradicting results within the well-studied arthropods, however, the role and origin of Dl/N signalling in segmentation generally is still unclear. In this study, we investigate core components of Dl/N signalling by means of gene expression analysis in the onychophoran Euperipatoides kanangrensis, a close relative to the arthropods. We find that neither Delta or Notch nor any other investigated components of its signalling pathway are likely to be involved in segment addition in onychophora

SUBMITTER: Janssen R 

PROVIDER: S-EPMC4819559 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature