Fluoxetine normalizes disrupted light-induced entrainment, fragmented ultradian rhythms and altered hippocampal clock gene expression in an animal model of high trait anxiety- and depression-related behavior.

ABSTRACT:

Introduction

Disturbances of circadian rhythms are a key symptom of mood and anxiety disorders. Selective serotonin reuptake inhibitors (SSRIs) - commonly used antidepressant drugs - also modulate aspects of circadian rhythmicity. However, their potential to restore circadian disturbances in depression remains to be investigated.

Materials and methods

The effects of the SSRI fluoxetine on genetically based, depression-related circadian disruptions at the behavioral and molecular level were examined using mice selectively bred for high anxiety-related and co-segregating depression-like behavior (HAB) and normal anxiety/depression behavior mice (NAB).

Results

The length of the circadian period was increased in fluoxetine-treated HAB as compared to NAB mice while the num

SUBMITTER: Schaufler J 

PROVIDER: S-EPMC4819589 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature