Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes.

ABSTRACT:

Objective

Gout, caused by hyperuricaemia, is a multifactorial disease. Although genome-wide association studies (GWASs) of gout have been reported, they included self-reported gout cases in which clinical information was insufficient. Therefore, the relationship between genetic variation and clinical subtypes of gout remains unclear. Here, we first performed a GWAS of clinically defined gout cases only.

Methods

A GWAS was conducted with 945 patients with clinically defined gout and 1213 controls in a Japanese male population, followed by replication study of 1048 clinically defined cases and 1334 controls.

Results

Five gout susceptibility loci were identified at the genome-wide significance level (p<5.0×10(-8)), which contained well-known urate transporter genes (ABCG

SUBMITTER: Matsuo H 

PROVIDER: S-EPMC4819613 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature