Distinct severity stages of obstructive sleep apnoea are correlated with unique dyslipidaemia: large-scale observational study.

ABSTRACT:

Background

Dyslipidaemia is an intermediary exacerbation factor for various diseases but the impact of obstructive sleep apnoea (OSA) on dyslipidaemia remains unclear.

Methods

A total of 3582 subjects with suspected OSA consecutively admitted to our hospital sleep centre were screened and 2983 (2422 with OSA) were included in the Shanghai Sleep Health Study. OSA severity was quantified using the apnoea-hypopnea index (AHI), the oxygen desaturation index and the arousal index. Biochemical indicators and anthropometric data were also collected. The relationship between OSA severity and the risk of dyslipidaemia was evaluated via ordinal logistic regression, restricted cubic spline (RCS) analysis and multivariate linear regressions.

Results

The RCS mapped a nonlinear dos

SUBMITTER: Guan J 

PROVIDER: S-EPMC4819621 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature