Ontology highlight
ABSTRACT:
SUBMITTER: Di Lascio S
PROVIDER: S-EPMC4819706 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Di Lascio Simona S Saba Elena E Belperio Debora D Raimondi Andrea A Lucchetti Helen H Fornasari Diego D Benfante Roberta R
Experimental cell research 20160219 1
PHOX2B and its paralogue gene PHOX2A are two homeodomain proteins in the network regulating the development of autonomic ganglia that have been associated with the pathogenesis of neuroblastoma (NB), because of their over-expression in different NB cell lines and tumour samples. We used the SK-N-BE(2)C cell line to show that all-trans retinoic acid (ATRA), a drug that is widely used to inhibit growth and induce differentiation in NBs, regulates both PHOX2A and PHOX2B expression, albeit by means ...[more]