Conditional Deletion of Hsd11b2 in the Brain Causes Salt Appetite and Hypertension.

ABSTRACT:

Background

The hypertensive syndrome of Apparent Mineralocorticoid Excess is caused by loss-of-function mutations in the gene encoding 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2), allowing inappropriate activation of the mineralocorticoid receptor by endogenous glucocorticoid. Hypertension is attributed to sodium retention in the distal nephron, but 11βHSD2 is also expressed in the brain. However, the central contribution to Apparent Mineralocorticoid Excess and other hypertensive states is often overlooked and is unresolved. We therefore used a Cre-Lox strategy to generate 11βHSD2 brain-specific knockout (Hsd11b2.BKO) mice, measuring blood pressure and salt appetite in adults.

Methods and results

Basal blood pressure, electrolytes, and circulating corticosteroids were

SUBMITTER: Evans LC 

PROVIDER: S-EPMC4819772 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature