Analysis of nanoparticle-protein coronas formed in vitro between nanosized welding particles and nasal lavage proteins.

ABSTRACT: Welding fumes include agglomerated particles built up of primary nanoparticles. Particles inhaled through the nose will to some extent be deposited in the protein-rich nasal mucosa, and a protein corona will be formed around the particles. The aim was to identify the protein corona formed between nasal lavage proteins and four types of particles with different parameters. Two of the particles were formed and collected during welding and two were manufactured iron oxides. When nasal lavage proteins were added to the particles, differences were observed in the sizes of the aggregates that were formed. Measurements showed that the amount of protein bound to particles correlated with the relative size increase of the aggregates, suggesting that the surface area was associated with the binding

SUBMITTER: Ali N 

PROVIDER: S-EPMC4819849 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature