Rectal Mechano-sensory Function in Patients with Carcinoid Diarrhea.

ABSTRACT:

Background/aims

In patients with neuroendocrine tumors, excessive production of serotonin and other amines may cause the carcinoid syndrome,which is mainly characterized by diarrhea and flushing. Little is known about the pathophysiology of carcinoid diarrhea. In severalother groups of patients, diarrhea may be associated with rectal hypersensitivity and increased rectal tone. Therefore, the aim of thepresent study was to compare rectal sensitivity and compliance in patients with carcinoid diarrhea and in healthy subjects.

Methods

Twelve patients (6 males, aged 54-78 years, median 65 years), with carcinoid diarrhea and 19 healthy subjects (7 males, aged 50-78 years, median 61 years) were included. Rectal mechanical and heat stimulation was used for assessment of rectal mecha

SUBMITTER: Gregersen T 

PROVIDER: S-EPMC4819865 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature