The Impact of Opioid Treatment on Regional Gastrointestinal Transit.

ABSTRACT:

Background/aims

To employ an experimental model of opioid-induced bowel dysfunction in healthy human volunteers, and evaluate the impact ofopioid treatment compared to placebo on gastrointestinal (GI) symptoms and motility assessed by questionnaires and regional GItransit times using the 3-dimensional (3D)-Transit system.

Methods

Twenty-five healthy males were randomly assigned to oxycodone or placebo for 5 days in a double blind, crossover design. AdverseGI effects were measured with the bowel function index, gastrointestinal symptom rating scale, patient assessment of constipationsymptom questionnaire, and Bristol stool form scale. Regional GI transit times were determined using the 3D-Transit system, and segmental transit times in the colon were determined using a custom

SUBMITTER: Poulsen JL 

PROVIDER: S-EPMC4819867 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature