Gene Expression Profiling of Tuberculous Meningitis Co-infected with HIV.

ABSTRACT: Tuberculous meningitis (TBM) is a fatal form of Mycobacterium tuberculosis infection of the central nervous system (CNS). The similarities in the clinical and radiological findings in TBM cases with or without HIV make the diagnosis very challenging. Identification of genes, which are differentially expressed in brain tissues of HIV positive and HIV negative TBM patients, would enable better understanding of the molecular aspects of the infection and would also serve as an initial platform to evaluate potential biomarkers. Here, we report the identification of 796 differentially regulated genes in brain tissues of TBM patients co-infected with HIV using oligonucleotide DNA microarrays. We also performed immunohistochemical validation and confirmed the abundance of four gene products

SUBMITTER: Kumar GS 

PROVIDER: S-EPMC4820295 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature