Aberrant neural function during emotion attribution in female subjects with fragile X syndrome.

ABSTRACT:

Objective

Fragile X (FraX) syndrome is caused by mutations of the FraX mental retardation-1 gene-a gene responsible for producing FraX mental retardation protein. The neurocognitive phenotype associated with FraX in female subjects includes increased risk for emotional disorders including social anxiety, depression, and attention deficit. Here, the authors investigated the neurobiological systems underlying emotion attribution in female subjects with FraX syndrome.

Method

While undergoing functional magnetic resonance imaging, 10 high-functioning female subjects with FraX syndrome and 10 typically developing (TD) female subjects were presented with photographs of happy, sad, and neutral faces and instructed to determine the facial emotion.

Results

No significant group

SUBMITTER: Hagan CC 

PROVIDER: S-EPMC4820328 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature