Computational Identification of Key Regulators in Two Different Colorectal Cancer Cell Lines.

ABSTRACT: Transcription factors (TFs) are gene regulatory proteins that are essential for an effective regulation of the transcriptional machinery. Today, it is known that their expression plays an important role in several types of cancer. Computational identification of key players in specific cancer cell lines is still an open challenge in cancer research. In this study, we present a systematic approach which combines colorectal cancer (CRC) cell lines, namely 1638N-T1 and CMT-93, and well-established computational methods in order to compare these cell lines on the level of transcriptional regulation as well as on a pathway level, i.e., the cancer cell-intrinsic pathway repertoire. For this purpose, we firstly applied the Trinity platform to detect signature genes, and then applied analyses of t

SUBMITTER: Wlochowitz D 

PROVIDER: S-EPMC4820448 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature