Ontology highlight
ABSTRACT:
SUBMITTER: Jun S
PROVIDER: S-EPMC4820809 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Nature communications 20160324
Despite the implication of Wnt signalling in radioresistance, the underlying mechanisms are unknown. Here we find that high Wnt signalling is associated with radioresistance in colorectal cancer (CRC) cells and intestinal stem cells (ISCs). We find that LIG4, a DNA ligase in DNA double-strand break repair, is a direct target of β-catenin. Wnt signalling enhances non-homologous end-joining repair in CRC, which is mediated by LIG4 transactivated by β-catenin. During radiation-induced intestinal re ...[more]