Experience-dependent hippocampal pattern differentiation prevents interference during subsequent learning.

ABSTRACT: The hippocampus is believed to reduce memory interference by disambiguating neural representations of similar events. However, there is limited empirical evidence linking representational overlap in the hippocampus to memory interference. Likewise, it is not fully understood how learning influences overlap among hippocampal representations. Using pattern-based fMRI analyses, we tested for a bidirectional relationship between memory overlap in the human hippocampus and learning. First, we show that learning drives hippocampal representations of similar events apart from one another. These changes are not explained by task demands to discriminate similar stimuli and are fully absent in visual cortical areas that feed into the hippocampus. Second, we show that lower representational overlap i

SUBMITTER: Favila SE 

PROVIDER: S-EPMC4820837 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature