Randomised trial of once-daily vilanterol in children with asthma on inhaled corticosteroid therapy.

ABSTRACT:

Background

Inhaled corticosteroids (ICS) are effective maintenance treatments for childhood asthma; however, many children remain uncontrolled. Vilanterol (VI) is an inhaled long-acting beta-2 agonist which, in combination with the ICS fluticasone furoate, is being explored as a once-daily treatment for asthma in children. We evaluated the dose-response, efficacy, and safety of once-daily VI (6.25 μg, 12.5 μg and 25 μg) administered in the evening over 4 weeks, on background fluticasone propionate (FP) in children with asthma inadequately controlled on ICS.

Methods

This was a Phase IIb, multicentre, randomised, double-blind, parallel-group, placebo-controlled study in children ages 5-11 years with persistent asthma on ICS and as-needed short-acting beta-agonist. The study co

SUBMITTER: Oliver AJ 

PROVIDER: S-EPMC4820901 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature