Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort.

ABSTRACT:

Background

Epidemiological studies have observed a positive association between an earlier age at sexual development and prostate cancer, but markers of sexual maturation in boys are imprecise and observational estimates are likely to suffer from a degree of uncontrolled confounding. To obtain causal estimates, we examined the role of pubertal development in prostate cancer using genetic polymorphisms associated with Tanner stage in adolescent boys in a Mendelian randomization (MR) approach.

Methods

We derived a weighted genetic risk score for pubertal development, combining 13 SNPs associated with male Tanner stage. A higher score indicated a later puberty onset. We examined the association of this score with prostate cancer risk, stage and grade in the UK-based ProtecT cas

SUBMITTER: Bonilla C 

PROVIDER: S-EPMC4820939 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature